The 506th Infantry Regiment, originally designated the 506th Parachute Infantry Regiment during World War II, is an airborne light infantry regiment of the United States Army. Currently a parent regiment under the U.S. Army Regimental System, the regiment has two active battalions: the 1st Battalion, 506th Infantry Regiment is assigned to the 1st Brigade Combat Team, 101st Airborne Division, and the 2nd Battalion, 506th Infantry Regiment is assigned to the 3rd Brigade Combat Team, 101st Airborne Division.

The 101st Airborne Division (Air Assault) ("Screaming Eagles") is a light infantry division of the United States Army that specializes in air assault operations. It can plan, coordinate, and execute multiple battalion-size air assault operations to seize terrain. These operations can be conducted by mobile teams covering large distances, fighting behind enemy lines, and working in austere environments with limited or degraded infrastructure. It was active in, for example, foreign internal defense and counterterrorism operations in Iraq, in Afghanistan in 2015–2016, and in Syria, as part of Operation Inherent Resolve in 2018–2021.