925 Grand is the former headquarters of the Federal Reserve Bank of Kansas City. It was the oldest Federal Reserve Bank building in active use until 2008, when the Kansas City Fed moved out. It was added to the National Register of Historic Places in 2007.

The Federal Reserve Bank of Kansas City is located in Kansas City, Missouri and covers the 10th District of the Federal Reserve, which includes Colorado, Kansas, Nebraska, Oklahoma, Wyoming, and portions of western Missouri and northern New Mexico. It is second only to the Federal Reserve Bank of San Francisco in size of geographic area served. Missouri is the only state with two main Federal Reserve Banks; the other is located in St. Louis.