The A6 is one of the main north–south roads in England. It runs from Luton in Bedfordshire to Carlisle in Cumbria, although it formerly started at a junction with the A1 at Barnet. It is the fourth longest numbered road in Britain; only the A1, A38 and A30 are longer.

The A57 is a major road in England. It runs east from Liverpool to Lincoln via Warrington, Salford and Manchester, and then through the Pennines over the Snake Pass (between the high moorlands of Bleaklow and Kinder Scout), around the Ladybower Reservoir, through Sheffield and past Worksop. Between Liverpool and Glossop, the road has largely been superseded by the M62, M602 and M67 motorways. Within Manchester a short stretch becomes the Mancunian Way, designated A57(M).