Aaron Albert Mossell II was the first African-American to graduate from the University of Pennsylvania Law School.

Nathan Francis Mossell was the first African-American graduate of the University of Pennsylvania School of Medicine in 1882. He did post-graduate training at hospitals in Philadelphia and London. In 1888, he was the first black physician elected as member of the Philadelphia County Medical Society in Pennsylvania. He helped found the Frederick Douglass Memorial Hospital and Training School in West Philadelphia in 1895, which he led as chief-of-staff and medical director until he retired in 1933. Gertrude Bustill Mossell was his wife.