Nathan Francis Mossell was the first African-American graduate of the University of Pennsylvania School of Medicine in 1882. He did post-graduate training at hospitals in Philadelphia and London. In 1888, he was the first black physician elected as member of the Philadelphia County Medical Society in Pennsylvania. He helped found the Frederick Douglass Memorial Hospital and Training School in West Philadelphia in 1895, which he led as chief-of-staff and medical director until he retired in 1933. Gertrude Bustill Mossell was his wife.

The University of Pennsylvania is a private Ivy League research university in Philadelphia, Pennsylvania, U.S. It is one of nine colonial colleges and was chartered prior to the U.S. Declaration of Independence when Benjamin Franklin, the university's founder and first president, advocated for an educational institution that trained leaders in academia, commerce, and public service. Penn identifies as the fourth oldest institution of higher education in the United States, though this representation is challenged by other universities, as Franklin first convened the board of trustees in 1749, arguably making it the fifth oldest institution of higher education in the U.S.