Aaron Burr Jr. was an American politician, businessman, lawyer, and Founding Father who served as the third vice president of the United States from 1801 to 1805 during Thomas Jefferson's first presidential term. He founded the Manhattan Company on September 1, 1799. Burr is remembered for his famous personal and political conflict with Alexander Hamilton, which culminated in the Burr–Hamilton duel in Weehawken, New Jersey on July 11, 1804. Burr mortally wounded Hamilton, who died from his wounds the following day.

The vice president of the United States (VPOTUS) is the second-highest officer in the executive branch of the U.S. federal government, after the president of the United States, and ranks first in the presidential line of succession. The vice president is also an officer in the legislative branch, as the president of the Senate. In this capacity, the vice president is empowered to preside over the United States Senate, but may not vote except to cast a tie-breaking vote. The vice president is indirectly elected together with the president to a four-year term of office by the people of the United States through the Electoral College. Since the passage of the Twenty-fifth Amendment to the US Constitution, the vice president may also be appointed by the president to fill a vacancy, via majority confirmation by both the Senate and the House.