Adenosine receptor
Videos
The adenosine receptors are a class of purinergic G protein-coupled receptors with adenosine as the endogenous ligand. There are four known types of adenosine receptors in humans: A1, A2A, A2B and A3;
Caffeine keeps you awake by blocking adenosine receptors.
Purinergic signalling
G protein-coupled receptor
Videos
G protein-coupled receptors, also known as seven--transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors, form a large group of evo
Adenosine receptor
…The adenosine receptors (or P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as the endogenous ligand. There are four known types of adenosine receptors in humans: A1, A2A, A2B and A3; each is encoded by a different…
Cartoon depicting the basic concept of GPCR conformational activation. Ligand binding disrupts an ionic lock between the E/DRY motif of TM-3 and acidic residues of TM-6. As a result, the GPCR reorganizes to allow activation of G-alpha proteins. The "side perspective" is a view from above and to the side of the GPCR as it is set in the plasma membrane (the membrane lipids have been omitted for clarity). The incorrectly labelled "intracellular perspective" shows an extracellular view looking down at the plasma membrane from outside the cell.
Cartoon depicting the heterotrimeric G-protein activation/deactivation cycle in the context of GPCR signaling
The effect of Rs and Gs in cAMP signal pathway
The effect of Ri and Gi in cAMP signal pathway