Adenylyl cyclase
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Adenylate cyclase is an enzyme with systematic name ATP diphosphate-lyase. It catalyzes the following reaction:
Adenylate cyclase (calmodulin sensitive) trimer, Bacillus anthracis Epinephrine binds its receptor, that associates with a heterotrimeric G protein. The G protein associates with adenylyl cyclase, which converts ATP to cAMP, spreading the signal.
Beta adrenergic receptor kinase pathway
Calmodulin
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Calmodulin is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the binding of Ca2+
Adenylyl cyclase
…alpha subunit. It is also regulated by forskolin, as well as other isoform-specific effectors: Isoforms I, III, and VIII are also stimulated by Ca2+/calmodulin. Isoforms V and VI are inhibited by Ca2+ in a calmodulin-independent manner…
The helix–loop–helix structure of the calcium-binding EF hand motif
Solution structure of Ca2+-calmodulin C-terminal domain
Solution structure of Ca2+-calmodulin N-terminal domain
Calmodulin bound to a peptide from MLC kinase (PDB: 2LV6)