Agriculture in Mexico has been an important sector of the country’s economy historically and politically even though it now accounts for a very small percentage of Mexico’s GDP. Mexico is one of the cradles of agriculture with the Mesoamericans developing domesticated plants such as maize, beans, tomatoes, squash, cotton, vanilla, avocados, cacao, various kinds of spices, and more. Domestic turkeys and Muscovy ducks were the only domesticated fowl in the pre-Hispanic period and small dogs were raised for food. There were no large domesticated animals.

Agriculture in Mesoamerica dates to the Archaic period of Mesoamerican chronology. At the beginning of the Archaic period, the Early Hunters of the late Pleistocene era led nomadic lifestyles, relying on hunting and gathering for sustenance. However, the nomadic lifestyle that dominated the late Pleistocene and the early Archaic slowly transitioned into a more sedentary lifestyle as the hunter gatherer micro-bands in the region began to cultivate wild plants. The cultivation of these plants provided security to the Mesoamericans, allowing them to increase surplus of "starvation foods" near seasonal camps; this surplus could be utilized when hunting was bad, during times of drought, and when resources were low. The cultivation of plants could have been started purposefully, or by accident. The former could have been done by bringing a wild plant closer to a camp site, or to a frequented area, so it was easier access and collect. The latter could have happened as certain plant seeds were eaten and not fully digested, causing these plants to grow wherever human habitation would take them.