State Route 69 is a 280-mile-long (450 km) state highway that extends from the southwestern to the northeastern parts of the U.S. state of Alabama. The southern terminus of the highway is at an intersection with SR 177 at Jackson. The northern terminus of the highway is at an intersection with US 431/SR 79 at Guntersville.

Clarke County is a county located in the southwestern part of the U.S. state of Alabama. As of the 2020 census, the population was 23,087. The county seat is Grove Hill. The county's largest city is Jackson. The county was created by the legislature of the Mississippi Territory in 1812. It is named in honor of General John Clarke of Georgia, who was later elected governor of that state.