Alfred E. Smith Career and Technical Education High School is a vocational public high school in the South Melrose neighborhood of The Bronx, New York. It was originally built in the early 20th century as the "Bronx Continuation School" for students who left the school system. The school eventually became a vocational high school in the 1920s. The school was named after the former New York governor and Democratic nominee for president, Alfred E. Smith in 1965. Its address is 333 E. 151 Street. The school is near the Third Avenue and E. 149th Street station of the 2 and 5 IRT trains. The principal is Evan Schwartz. This is the school at which Evan Hunter,, spent 17 days as a teacher, in September 1950. The experience gave him the insights for his novel, 'The Blackboard Jungle' (1954), written under the Hunter penname, which was adapted into the film, Blackboard Jungle (1955).

Melrose is a mostly residential neighborhood in the southwestern section of the New York City borough of the Bronx. It adjoins the business and one-time theater area known as The Hub. Melrose is rectangular-shaped, being bordered by Saint Anns Avenue on the east, 149th Street on the south, Park Avenue on the west, and 163rd Street to the north. Melrose Avenue and Third Avenue are the primary thoroughfares through Melrose.