Alpine is a city in and the county seat of Brewster County, Texas, United States. The population was 6,035 at the 2020 census. The town has an elevation of 4,462 feet (1,360 m), and the surrounding mountain peaks are over 1 mile (1.6 km) above sea level. A university, hospital, library, and retail make Alpine the center of the sprawling 12,000 square miles (3,108,000 ha) but wide open Big Bend area including Brewster, Presidio, and Jeff Davis counties.

Brewster County is a county located in the U.S. state of Texas. It is in West Texas and its county seat is Alpine. It is one of the nine counties that comprise the Trans-Pecos region, and borders Mexico. Brewster County is the largest county by area in the state - at 6,192 square miles (16,040 km2) it is over three times the size of the state of Delaware, and more than 500 square miles (1,300 km2) bigger than Connecticut.