Amboy is an unincorporated community in San Bernardino County, in California's Mojave Desert, west of Needles and east of Ludlow on historic Route 66. It is roughly 60 miles (97 km) northeast of Twentynine Palms. As of 2020, the town's business district still contained a post office, a historic restaurant-motel, and a Route 66 tourist shop, all operated by the town's population of four people.

Interstate 40 (I-40) is a major east–west Interstate Highway in the United States, stretching from Barstow, California, to Wilmington, North Carolina. The segment of I-40 in California is sometimes called the Needles Freeway. It passes through the eastern fringe of the Inland Empire metropolitan area, going east from its western terminus at I-15 in Barstow across the Mojave Desert in San Bernardino County past the Clipper Mountains to Needles, before it crosses over the Colorado River into Arizona east of Needles. All 155 miles (249 km) of I-40 in California are in San Bernardino County.