U.S. Route 66 is a part of a former United States Numbered Highway in the state of California that ran from the west in Santa Monica on the Pacific Ocean through Los Angeles and San Bernardino to Needles at the Arizona state line. It was truncated during the 1964 renumbering and its signage removed in 1974. The highway is now mostly replaced with several streets in Los Angeles, State Route 2 (SR 2), SR 110, SR 66, San Bernardino County Route 66 (CR 66), Interstate 15 (I-15), and I-40.

State Route 2 (SR 2) is a state highway in the U.S. state of California. It connects the Los Angeles Basin with the San Gabriel Mountains and the Victor Valley in the Mojave Desert. The highway's southwestern end is at the intersection of Centinela Avenue at the Santa Monica-Los Angeles border and its northeastern end is at SR 138 east of Wrightwood. The SR 2 is divided into four segments, and it briefly runs concurrently with U.S. Route 101 (US 101) and Interstate 210 (I-210). The southwestern section of SR 2 runs along a segment of the east–west Santa Monica Boulevard, an old routing of US 66, to US 101 in East Hollywood; the second section runs along segments of both the north–south Alvarado Street and Glendale Boulevard in Echo Park; the third section to I-210 in Glendale is known as the north–south Glendale Freeway; and the northeastern portion from I-210 in La Cañada Flintridge to SR 138 is designated as the Angeles Crest Highway.