The American Anti-Slavery Society was an abolitionist society founded by William Lloyd Garrison and Arthur Tappan. Frederick Douglass, an escaped slave, had become a prominent abolitionist and was a key leader of this society, who often spoke at its meetings. William Wells Brown, also a freedman, also often spoke at meetings. By 1838, the society had 1,350 local chapters with around 250,000 members.

Susan B. Anthony was an American social reformer and women's rights activist who played a pivotal role in the women's suffrage movement. Born into a Quaker family committed to social equality, she collected anti-slavery petitions at the age of 17. In 1856, she became the New York state agent for the American Anti-Slavery Society.