American Express Company (Amex) is an American bank holding company and multinational financial services corporation that specializes in payment cards. It is headquartered at 200 Vesey Street, also known as American Express Tower, in the Battery Park City neighborhood of Lower Manhattan. Amex is the fourth-largest card network globally based on purchase volume, behind China UnionPay, Visa, and Mastercard. 133.3 million Amex cards were in force worldwide as of December 31, 2022, with an average annual spend per card member of US$23,496. That year, Amex handled over $1.6 trillion in purchase volume on its network. Amex is one of the largest US banks, and is ranked 77th on the Fortune 500 and 28th on the list of the most valuable brands by Forbes. In 2023, it was ranked 63rd in the Forbes Global 2000. Amex also owns a direct bank.

200 Vesey Street, formerly known as Three World Financial Center and also known as the American Express Tower, is one of four towers that comprise the Brookfield Place complex in the Financial District of Lower Manhattan in New York City. Rising 51 floors and 739 feet (225 m), it is situated between the Hudson River and the World Trade Center. The building opened in 1986 as part of the World Financial Center and was designed by Haines Lundberg Waehler and Cesar Pelli & Associates.