The American Jazz Museum is located in the historic 18th and Vine district of Kansas City, Missouri. The museum preserves the history of American jazz music, with exhibits on Charlie Parker, Duke Ellington, Louis Armstrong, Ella Fitzgerald and others. Nested within the museum is a fully functioning jazz club, The Blue Room, which holds live performances multiple nights a week.

18th and Vine is a neighborhood of Kansas City, Missouri. It is internationally recognized as a historical point of origin of jazz music and a historic hub of African-American businesses. Along with Basin Street in New Orleans, Beale Street in Memphis, 52nd Street in New York City, and Central Avenue in Los Angeles, the 18th and Vine area fostered a new style of jazz. Kansas City jazz is a riff-based and blues-influenced sound developed in jam sessions in the neighborhood's crowded clubs. Many notable jazz musicians of the 1930s and 1940s lived or got started here, including Charlie Parker. Due to this legacy, U.S. Representative Emanuel Cleaver said 18th and Vine is America's third most recognized street after Broadway and Hollywood Boulevard.