Amherst is a town in Hillsborough County in the state of New Hampshire, United States. The population was 11,753 at the 2020 census. Amherst is home to Ponemah Bog Wildlife Sanctuary, Hodgman State Forest, the Joe English Reservation and Baboosic Lake.

New Hampshire Route 101 is a state-maintained highway in southern New Hampshire extending from Keene to Hampton Beach. It is the major east–west highway in the southern portion of the state. Most of its eastern portion is a major freeway linking the greater Manchester area to the Seacoast Region. At 95.189 miles (153.192 km) in length, NH 101 nearly spans the entire width of southern New Hampshire.