Amrullah Saleh is an Afghan politician who served as the first vice president of Afghanistan from February 2020 to August 2021, and acting interior minister from 2018 to 2019. He was the head of the National Directorate of Security (NDS) from 2004 to 2010.

The vice president of the Islamic Republic of Afghanistan was the second highest political position attainable in the Islamic Republic of Afghanistan. The vice presidents were elected on the same ticket as the president. A presidential candidate was responsible for nominating two candidates for vice president before the election.