Amyloid
Videos
Amyloids are aggregates of proteins characterised by a fibrillar morphology of typically 7–13 nm in diameter, a β-sheet secondary structure and ability to be stained by particular dyes, such as Congo
Micrograph showing amyloid deposits (pink) in small bowel. Duodenum with amyloid deposition in lamina propria. Amyloid shows up as homogeneous pink material in lamina propria and around blood vessels. 20× magnification.
Amyloid of HET-s(218–289) prion pentamer, Podospora anserina (PDB: 2rnm)
Structure of a fibril, consisting of one single protofilament, of the amyloid β peptide viewed down the long axis of the fibril (PDB: 2mlq)
Mechanisms of amyloid fibril formation including nucleated polymerisation (red arrows), nucleated conformational conversion (blue arrows), native-like aggregation (green arrows) and secondary processes (right)
Congo red
Videos
Congo red is an organic compound, the sodium salt of 3,3′-bis. It is an azo dye. Congo red is water-soluble, yielding a red colloidal solution; its solubility is greater in organic solvents. The use o
Amyloid
…morphology of typically 7–13 nm in diameter, a β-sheet secondary structure (known as cross-β) and ability to be stained by particular dyes, such as Congo red. In the human body, amyloids have been linked to the development of various diseases. Pathogenic amyloids form when previously healthy proteins lose…
Congo red solid and in water solution
Micrograph demonstrating amyloid deposition (red-orange) with Congo red staining in cardiac amyloidosis