Amyloid plaques
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Amyloid plaques are extracellular deposits of amyloid, consisting of amyloid beta protein, that present mainly in the grey matter of the brain in humans and other primates. Degenerative neuronal eleme
Amyloid beta immunostaining showing amyloid plaques (brown)
Two amyloid plaques from the brain of a patient with Alzheimer's disease. In this photomicrograph, neurites are darkly stained with the Naoumenko-Feigin silver method, and the pink elements (including the plaque cores) are stained with the periodic acid-Schiff (PAS) counterstain. The bar is 20 microns (0.02 mm) in length.
Microglia
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Microglia are a type of glial cell located throughout the brain and spinal cord of the central nervous system. Microglia account for around 5–10% of cells found within the brain. As the resident macro
Amyloid plaques
…beta (Aβ) protein, that present mainly in the grey matter of the brain in humans and other primates. Degenerative neuronal elements and an abundance of microglia and astrocytes can be associated with amyloid plaques. Some plaques occur in the brain as a result of aging, but large numbers of plaques and neurofibrillary…
Microglia in resting state from rat cortex before traumatic brain injury (lectin staining with HRP)
Microglia/macrophage – activated form from rat cortex after traumatic brain injury (lectin staining with HRP)
Rat microglia grown in tissue culture in green, along with nerve fiber processes shown in red.
Microglia in rat cerebellar molecular layer in red, stained with antibody to IBA1/AIF1. Bergmann glia processes are shown in green, DNA in blue.