Andrea Vendramin served as Doge of Venice, 1476–78, at the height of Venetian power, the only member of the Vendramin family to do so. His mother, Maria Michiel, and his wife Regina Gradenigo, both came from Dogal families. He had served as Venetian Procurator in Rome, and his brief reign was largely concerned with the end of the Second Turkish–Venetian War. He probably died of plague.

The House of Vendramin was a rich merchant family of Venice, Italy, who were among the case nuove or "new houses" who joined the patrician class when the Libro d'Oro was opened after the battle of Chioggia. Andrea Vendramin served as the sole Vendramin Doge from 1476–78, at the height of Venetian power, though in 1477 an Antonio Feleto was imprisoned, then banished, for remarking in public that the Council of the Forty-One must have been hard-pressed to elect a cheesemonger Doge. In his youth, Andrea and his brother Luca, in joint ventures, used to ship from Alexandria enough goods to fill a galley or a galley and a half, Malipiero recorded in retrospect: even his factors grew rich managing his affairs. At this period, mentions of Vendramins in various fields of business occur; Luca Vendramin (d.1527) founded a successful bank on the still-wooden Rialto Bridge with three Capelli brothers in 1507, but in his will of 1524 forbade his sons from continuing in banking. An early text on accounting mentions that the Vendramins' soap is so reliably good that you can buy it without inspecting it. Later they owned an important theatre.