Anne Shakespeare was the wife of William Shakespeare, an English poet, playwright and actor. They were married in 1582, when Hathaway was 26 years old and Shakespeare was 18. She outlived her husband by seven years. Very little is known about her life beyond a few references in legal documents. Her personality and relationship to Shakespeare have been the subject of much speculation by many historians and writers.

Hamnet Shakespeare was the only son of William Shakespeare and Anne Hathaway, and the fraternal twin of Judith Shakespeare. He died at the age of 11. Some Shakespearean scholars speculate on the relationship between Hamnet and his father's later play Hamlet, as well as on possible connections between Hamnet's death and the writing of King John, Romeo and Juliet, Julius Caesar, and Twelfth Night.