Anniston is the county seat of Calhoun County in Alabama, United States, and is one of two urban centers/principal cities of and included in the Anniston-Oxford Metropolitan Statistical Area. As of the 2010 census, the population of the city was 23,106. According to 2019 Census estimates, the city had a population of 21,287. Named "The Model City" by Atlanta newspaperman Henry W. Grady for its careful planning in the late 19th century, the city is situated on the slope of Blue Mountain.

Calhoun County is a county in the east central part of the U.S. state of Alabama. As of the 2020 census, the population was 116,441. Its county seat is Anniston. It is named in honor of John C. Calhoun, a US Senator from South Carolina.