The Anti-Masonic Party was the earliest third party in the United States. Formally a single-issue party, it strongly opposed Freemasonry in the United States. It was active from the late 1820s, especially in the Northeast, and later attempted to become a major party by expanding its platform to take positions on other issues. It declined quickly after 1832 as most members joined the new Whig Party; it disappeared after 1838.

The Whig Party was a political party that existed in the United States during the mid-19th century. Alongside the slightly larger Democratic Party, it was one of the two major parties in the United States between the late 1830s and the early 1850s as part of the Second Party System. Four presidents were affiliated with the Whig Party for at least part of their terms. Other prominent members of the Whig Party include Henry Clay, Daniel Webster, Rufus Choate, William Seward, John J. Crittenden, and John Quincy Adams. The Whig base of support was centered among entrepreneurs, professionals, planters, social reformers, devout Protestants, and the emerging urban middle class. It had much less backing from poor farmers and unskilled workers.