Antofagasta Province is one of three provinces in the northern Chilean region of Antofagasta (II). The capital is the port city of Antofagasta. Located within the Atacama Desert, it borders the El Loa and Tocopilla provinces to the north, the Pacific Ocean to the West and the Atacama Region to the south.

The Antofagasta Region is one of Chile's sixteen first-order administrative divisions. The second-largest region of Chile in area, it comprises three provinces, Antofagasta, El Loa and Tocopilla. It is bordered to the north by Tarapacá, by Atacama to the south, and to the east by Bolivia and Argentina. The region's capital is the port city of Antofagasta; another one of its important cities is Calama. The region's main economic activity is copper mining in its giant inland porphyry copper systems.