Apollo 8 was the first crewed spacecraft to leave low Earth orbit and the first human spaceflight to reach the Moon. The crew orbited the Moon ten times without landing, and then departed safely back to Earth. These three astronauts—Frank Borman, James Lovell, and William Anders—were the first humans to witness and photograph the far side of the Moon and an Earthrise.

Human spaceflight is spaceflight with a crew or passengers aboard a spacecraft, often with the spacecraft being operated directly by the onboard human crew. Spacecraft can also be remotely operated from ground stations on Earth, or autonomously, without any direct human involvement. People trained for spaceflight are called astronauts, cosmonauts (Russian), or taikonauts (Chinese); and non-professionals are referred to as spaceflight participants or spacefarers.