The Apollo primary guidance, navigation, and control system was a self-contained inertial guidance system that allowed Apollo spacecraft to carry out their missions when communications with Earth were interrupted, either as expected, when the spacecraft were behind the Moon, or in case of a communications failure. The Apollo command module (CM) and lunar module (LM), were each equipped with a version of PGNCS. PGNCS, and specifically its computer, were also the command center for all system inputs from the LM, including the alignment optical telescope, the radar system, the manual translation and rotation device inputs by the astronauts as well as other inputs from the LM systems.

An inertial navigation system is a navigation device that uses motion sensors (accelerometers), rotation sensors (gyroscopes) and a computer to continuously calculate by dead reckoning the position, the orientation, and the velocity of a moving object without the need for external references. Often the inertial sensors are supplemented by a barometric altimeter and sometimes by magnetic sensors (magnetometers) and/or speed measuring devices. INSs are used on mobile robots and on vehicles such as ships, aircraft, submarines, guided missiles, and spacecraft. Older INS systems generally used an inertial platform as their mounting point to the vehicle and the terms are sometimes considered synonymous.