Appalachian Development Highway System
…Prestonsburg. It forms part of a route from Lexington, Kentucky to Roanoke, Virginia using Interstate 64 (I-64), Corridor I, Corridor R, Corridor B, Corridor Q, and I-81. Corridor S is a highway in the U.S. state of Tennessee. It is routed entirely along U.S. Route 25E (US 25E); from Interstate 81 (I-81), near…