Interstate 22 (I-22) is a 202.22-mile-long (325.44 km) Interstate Highway in the US states of Mississippi and Alabama, connecting I-269 near Byhalia, Mississippi, to I-65 near Birmingham, Alabama. I-22 is also Corridor X of the Appalachian Development Highway System (ADHS). Designated in 2012, I-22 follows the route of older U.S. Route 78 (US 78) and is concurrent with the route for all but its eastern most 11 miles (18 km). The freeway mainly spans rural areas and passes numerous small towns along its route, including Fulton, Tupelo, New Albany, and Holly Springs in Mississippi and Jasper, Winfield, and Hamilton in Alabama.

Interstate 269 (I-269) is a beltway around the city of Memphis, Tennessee, and its adjacent suburban areas in southwestern Tennessee and northern Mississippi, completed in October 2018. I-269 was planned and built to serve as an outer bypass for the Memphis metropolitan area, funneling through traffic around the metro area while also functioning as a bypass of future I-69, which will run directly through the center of the metro area. I-269 currently connects to its parent route, I-69, at an interchange in Hernando, Mississippi, and will do so again in Millington, Tennessee, in the future.