Espiritu Santo Parish, now known as the Archdiocesan Shrine of Espiritu Santo, is a Roman Catholic parish church belonging to the Archdiocese of Manila that is located at 1912 Rizal Avenue corner Tayuman Street, Santa Cruz, Manila, Philippines. It was declared an Archdiocesan Shrine by Cardinal Luis Antonio G. Tagle, Archbishop Emeritus of Manila, on June 8, 2014, the Solemnity of the Pentecost. Eymard Dennis Peter Marcelino S. Odiver is the current parish priest and rector of the church since 2022.

Rizal Avenue, also known as Avenida or Avenida Rizal, is one of Manila's main thoroughfares running from its Santa Cruz and Quiapo districts to the Bonifacio Monument (Monumento) Circle in Caloocan. Named after the national hero José Rizal, it is a part of Radial Road 9 (R-9). The LRT Line 1 elevated railroad is built above the street in its entire length, and several jeepneys ply the area taking passengers from Caloocan, Quezon City, and Valenzuela. Most of the street is within Santa Cruz, Manila. By the 1960s, economic activities shifted from Binondo to Makati. The avenue forms part of National Route 150 (N150) of the Philippine highway network.