Aridoamerica denotes an ecological region spanning Northern Mexico and the Southwestern United States, defined by the presence of the culturally significant staple foodstuff Phaseolus acutifolius, a drought-resistant bean. Its dry, arid climate and geography stand in contrast to the verdant Mesoamerica of present-day central Mexico into Central America to the south and east, and the higher, milder "island" of Oasisamerica to the north. Aridoamerica overlaps with both.

Mesoamerica is a historical region and cultural area that begins in the southern part of North America and extends to the Pacific coast of Central America, thus comprising the lands of central and southern Mexico, all of Belize, Guatemala, El Salvador, and small parts of Honduras, Nicaragua and Costa Rica. As a cultural area, Mesoamerica is defined by a mosaic of cultural traits developed and shared by its indigenous cultures.