Arkansas City is a town in Desha County, Arkansas, United States. The population was 376 at the 2010 census. The town is the county seat of Desha County. Arkansas City Commercial District, located at Desoto Avenue and Sprague Street, is listed on the National Register of Historic Places.

Desha County is a county located in the southeast part of the U.S. state of Arkansas, with its eastern border the Mississippi River. At the 2020 census, the population was 11,395. The county seat is Arkansas City.