Desha County is a county located in the southeast part of the U.S. state of Arkansas, with its eastern border the Mississippi River. At the 2020 census, the population was 11,395. The county seat is Arkansas City.

Arkansas is a landlocked state in the South Central region of the Southern United States. It borders Missouri to the north, Tennessee and Mississippi to the east, Louisiana to the south, Texas to the southwest, and Oklahoma to the west. Its name derives from the Osage language, and refers to their relatives, the Quapaw people. The state's diverse geography ranges from the mountainous regions of the Ozark and Ouachita Mountains, which make up the U.S. Interior Highlands, to the densely forested land in the south known as the Arkansas Timberlands, to the eastern lowlands along the Mississippi River and the Arkansas Delta.