Highway 22 is an east–west state highway in the Arkansas River Valley. It is maintained by the Arkansas State Highway and Transportation Department (AHTD). The highway runs 75.60 miles (121.67 km) from US 64/US 71B east to Highway 7 in Dardanelle. Following the historic stagecoach line of the cross-country Butterfield Trail, the highway is one of the original 1926 state highways. It is designated by the AHTD as the True Grit Trail.

The Arkansas River Valley is a region in Arkansas defined by the Arkansas River in the western part of the state. Generally defined as the area between the Ozark and Ouachita Mountains, the River Valley is characterized by flat lowlands covered in fertile farmland and lakes periodically interrupted by high peaks. Mount Magazine, Mount Nebo, and Petit Jean Mountain compose the Tri-Peaks Region, a further subdivision of the River Valley popular with hikers and outdoors enthusiasts. In addition to the outdoor recreational activities available to residents and visitors of the region, the River Valley contains Arkansas's wine country as well as hundreds of historical sites throughout the area. It is one of six natural divisions of Arkansas.