Highway 22 is an east–west state highway in the Arkansas River Valley. It is maintained by the Arkansas State Highway and Transportation Department (AHTD). The highway runs 75.60 miles (121.67 km) from US 64/US 71B east to Highway 7 in Dardanelle. Following the historic stagecoach line of the cross-country Butterfield Trail, the highway is one of the original 1926 state highways. It is designated by the AHTD as the True Grit Trail.

Highway 255 is a designation for two north–south state highways in Sebastian County. An eastern route of 7.37 miles (11.86 km) runs north from Highway 22 through Lavaca to terminate at Highway 22 in Central City. A second route of 17.21 miles (27.70 km) begins at Highway 22 in Barling and runs to US Route 64/U.S. Route 71B (US 64/US 71B).