The Arkansas River Valley is a region in Arkansas defined by the Arkansas River in the western part of the state. Generally defined as the area between the Ozark and Ouachita Mountains, the River Valley is characterized by flat lowlands covered in fertile farmland and lakes periodically interrupted by high peaks. Mount Magazine, Mount Nebo, and Petit Jean Mountain compose the Tri-Peaks Region, a further subdivision of the River Valley popular with hikers and outdoors enthusiasts. In addition to the outdoor recreational activities available to residents and visitors of the region, the River Valley contains Arkansas's wine country as well as hundreds of historical sites throughout the area. It is one of six natural divisions of Arkansas.

Arkansas is a landlocked state in the South Central region of the Southern United States. It borders Missouri to the north, Tennessee and Mississippi to the east, Louisiana to the south, Texas to the southwest, and Oklahoma to the west. Its name derives from the Osage language, and refers to their relatives, the Quapaw people. The state's diverse geography ranges from the mountainous regions of the Ozark and Ouachita Mountains, which make up the U.S. Interior Highlands, to the densely forested land in the south known as the Arkansas Timberlands, to the eastern lowlands along the Mississippi River and the Arkansas Delta.