Arkansas Highway 59 is a north–south state highway in Northwest Arkansas. The route runs 93.24 miles (150.06 km) from Arkansas Highway 22 in Barling north to the Missouri state line through Van Buren, the county seat of Crawford County. Highway 59 parallels US 59 between Siloam Springs and Fort Smith. Since US 59 goes through Arkansas, AR 59 is the only Arkansas state highway to share its numbering with a federal highway that goes through Arkansas.

Northwest Arkansas (NWA) is a metropolitan area and region in Arkansas within the Ozark Mountains. It includes four of the ten largest cities in the state: Fayetteville, Springdale, Rogers, and Bentonville, the surrounding towns of Benton and Washington counties, and adjacent rural Madison County, Arkansas. The United States Census Bureau-defined Fayetteville–Springdale–Rogers Metropolitan Statistical Area includes 3,213.01 square miles (8,321.7 km2) and 576,403 residents, ranking NWA as the 98th most-populous metropolitan statistical area in the U.S. and the 13th fastest growing in the United States.