Arroyo Grande Valley is an American Viticultural Area (AVA) located in San Luis Obispo County, California approximately 12 miles (19 km) southeast of the county seat San Luis Obispo. Arroyo Grande Valley was recognized on February 5, 1990 by the Bureau of Alcohol, Tobacco, Firearms and Explosives (ATF) as the state's 60th AVA based on the petition filed in 1987 by Don Talley of Talley Vineyards and William S. Greenough of Saucelito Canyon Vineyard for the establishment of the "Arroyo Grande Valley" viticultural area in San Luis Obispo County. The 16 miles (26 km) long, approximately 67 square miles valley appellation benefits from its east-northeast orientation allowing the breeze from the Pacific Ocean to moderate the climate of the area. The valley is divided by a fog line produced by the cool maritime layer where Zinfandel, Petite Sirah and Rhône varietals are grown on the higher elevations near Lopez Lake and the cooler mid-valley vineyards being home to Chardonnay and Pinot noir. On April 8, 2022, the Alcohol and Tobacco Tax and Trade Bureau (TTB) approved the designation of the expansive San Luis Obispo (SLO) Coast AVA overlapping the boundaries of Edna Valley and Arroyo Grande Valley viticultural areas because they share common features. However, these two previously established areas still have unique characteristics to retain their viticultural area distinctions within SLO Coast. Edna Valley lies immediately to the northwest, the Los Padres National Forest straddles the north leg boundary, the Santa Maria Valley AVA lies to the southeast of Arroyo Grande Valley, and the Pacific Ocean communities of Oceano, Grover City and Arroyo Grande abut its southwestern border.

San Luis Obispo (SLO) County wine is a appellation that designates wine made from grapes grown in San Luis Obispo (SLO) County, California which is sandwiched between Santa Barbara County to the south and Monterey County at the northern boundary on the Pacific coast. Its location sits halfway between the cities of San Francisco and Los Angeles on the north–south axis of U.S. Route 101 and Pacific Coast Highway (PCH). The county lies entirely within the Central Coast viticultural area. County names in the United States automatically qualify as legal appellations of origin for wine produced from grapes grown in that county and do not require registration with the Alcohol and Tobacco Tax and Trade Bureau (TTB) of the Treasury Department. TTB was created in January of 2003, when the Bureau of Alcohol, Tobacco and Firearms, or ATF, was extensively reorganized under the provisions of the Homeland Security Act of 2002.