Artsakh was the tenth province (nahang) of the Kingdom of Armenia from c. 189 BC until 387 AD, when it was made part of Caucasian Albania, a subject principality of the Sasanian Empire, following the Peace of Acilisene. From the 7th to 9th centuries, it fell under Arab control. In 821, it formed the Armenian principality of Khachen and around the year 1000 was proclaimed the Kingdom of Artsakh, one of the last medieval eastern Armenian kingdoms and principalities to maintain its autonomy following the Turkic invasions of the 11th to 14th centuries.

The Armenian highlands is the most central and the highest of the three plateaus that together form the northern sector of West Asia. Clockwise starting from the west, the Armenian highlands are bounded by the Anatolian plateau, the Caucasus, the Kura-Aras lowlands, the Iranian Plateau, and Mesopotamia. The highlands are divided into western and eastern regions, defined by the Ararat Valley where Mount Ararat is located. Western Armenia is nowadays referred to as eastern Anatolia, and Eastern Armenia as the Lesser Caucasus or Caucasus Minor, and historically as the Anti-Caucasus, meaning "opposite the Caucasus".