The Atacama Region is one of Chile's 16 first order administrative divisions. It comprises three provinces: Chañaral, Copiapó and Huasco. It is bordered to the north by Antofagasta, to the south by Coquimbo, to the east by the provinces of Catamarca, La Rioja and San Juan of Argentina, and to the west by the Pacific Ocean. The regional capital Copiapó is located 806 km (501 mi) north of the country's capital of Santiago. The region occupies the southern portion of the Atacama Desert, the rest of the desert is mainly distributed among the other regions of Norte Grande.

The Antofagasta Region is one of Chile's sixteen first-order administrative divisions. The second-largest region of Chile in area, it comprises three provinces, Antofagasta, El Loa and Tocopilla. It is bordered to the north by Tarapacá, by Atacama to the south, and to the east by Bolivia and Argentina. The region's capital is the port city of Antofagasta; another one of its important cities is Calama. The region's main economic activity is copper mining in its giant inland porphyry copper systems.