The Atlas-Agena was an American expendable launch system derived from the SM-65 Atlas missile. It was a member of the Atlas family of rockets, and was launched 109 times between 1960 and 1978. It was used to launch the first five Mariner uncrewed probes to the planets Venus and Mars, and the Ranger and Lunar Orbiter uncrewed probes to the Moon. The upper stage was also used as an uncrewed orbital target vehicle for the Gemini crewed spacecraft to practice rendezvous and docking. However, the launch vehicle family was originally developed for the Air Force and most of its launches were classified DoD payloads.

Atlas is a family of US missiles and space launch vehicles that originated with the SM-65 Atlas. The Atlas intercontinental ballistic missile (ICBM) program was initiated in the late 1950s under the Convair Division of General Dynamics. Atlas was a liquid propellant rocket burning RP-1 kerosene fuel with liquid oxygen in three engines configured in an unusual "stage-and-a-half" or "parallel staging" design: two outboard booster engines were jettisoned along with supporting structures during ascent, while the center sustainer engine, propellant tanks and other structural elements remained connected through propellant depletion and engine shutdown.