Atlas V is an expendable launch system and the fifth major version in the Atlas launch vehicle family. It was originally designed by Lockheed Martin, now being operated by United Launch Alliance (ULA), a joint venture between Lockheed Martin and Boeing. It is used for DoD, NASA, and Commercial payloads. It is America's longest-serving active rocket. After 87 launches, in August 2021 ULA announced that Atlas V would be retired, and all 29 remaining launches had been sold. As of January 2024, 17 launches remain. Other future ULA launches will use the new Vulcan Centaur rocket.

An expendable launch system is a launch vehicle that can be launched only once, after which its components are either destroyed during reentry or discarded in space. ELVs typically consist of several rocket stages that are discarded sequentially as their fuel is exhausted and the vehicle gains altitude and speed. As of 2024, less and less satellites and human spacecraft are launched on ELVs in favor of reusable launch vehicles. However, there are many instances where a ELV may still have a compelling use case over a reusable vehicle. ELVs are simpler in design than reusable launch systems and therefore may have a lower production cost. Furthermore, an ELV can use its entire fuel supply to accelerate its payload, offering greater payloads. ELVs are proven technology in widespread use for many decades.