Atlas V is an expendable launch system and the fifth major version in the Atlas launch vehicle family. It was originally designed by Lockheed Martin, now being operated by United Launch Alliance (ULA), a joint venture between Lockheed Martin and Boeing. It is used for DoD, NASA, and Commercial payloads. It is America's longest-serving active rocket. After 87 launches, in August 2021 ULA announced that Atlas V would be retired, and all 29 remaining launches had been sold. As of January 2024, 17 launches remain. Other future ULA launches will use the new Vulcan Centaur rocket.

The Centaur is a family of rocket propelled upper stages that has been in use since 1962. It is currently produced by U.S. launch service provider United Launch Alliance, with one main active version and one version under development. The 3.05 m (10.0 ft) diameter Common Centaur/Centaur III flies as the upper stage of the Atlas V launch vehicle, and the 5.4 m (18 ft) diameter Centaur V has been developed as the upper stage of ULA's new Vulcan rocket. Centaur was the first rocket stage to use liquid hydrogen (LH2) and liquid oxygen (LOX) propellants, a high-energy combination that is ideal for upper stages but has significant handling difficulties.