Avianca Cargo is a cargo airline based at José María Córdova International Airport in Medellín, Colombia. It is an all-cargo airline transporting flowers from Latin America to Miami, as well as general cargo throughout the Americas.

Cargo airlines are airlines mainly dedicated to the transport of cargo by air. Some cargo airlines are divisions or subsidiaries of larger passenger airlines. In 2018, airline cargo traffic represented 262,333 million tonne-kilometres with a 49.3% load factor: 52.1% for dedicated cargo operations, and 47.9% within mixed operations.