Baie-Comeau is a city located approximately 420 km (260 mi) north-east of Quebec City in the Côte-Nord region of the province of Quebec, Canada. It is located on the shores of the Saint Lawrence River near the mouth of the Manicouagan River, and is the seat of Manicouagan Regional County Municipality.

Côte-Nord is a region of 247,655.33 square kilometres (95,620.26 sq mi), the second-largest administrative region in Québec Province, Canada, behind Nord-du-Québec. It covers much of the northern shore of the Saint Lawrence River estuary and the Gulf of Saint Lawrence past Tadoussac.