Barbara Bush was the first lady of the United States from 1989 to 1993, as the wife of George H. W. Bush, the 41st president of the United States. She was previously the second lady of the United States from 1981 to 1989, and founded the Barbara Bush Foundation for Family Literacy. Among her children are George W. Bush, the 43rd president of the United States, and Jeb Bush, the 43rd governor of Florida. She and Abigail Adams are the only two women to be the wife of one U.S. president and the mother of another. At the time she became first lady, she was the second oldest woman to hold the position, behind only Anna Harrison, who never lived in the capital. Bush was generally popular as first lady, recognized for her apolitical grandmotherly image.

The second gentleman or second lady of the United States is the informal title held by the spouse of the vice president of the United States, concurrent with the vice president's term of office. Coined in contrast to "first lady" – albeit used less commonly – the title "second lady" was apparently first used by Jennie Tuttle Hobart to refer to herself. The first second gentleman of the United States is Doug Emhoff, the husband of Kamala Harris, the current vice president and first female in the position, since January 20, 2021.