The Basilica of Saint Mary is a Roman Catholic minor basilica located on its own city block along Hennepin Avenue between 16th and 17th Streets in downtown Minneapolis, Minnesota. It was the first basilica established in the United States. The Basilica of Saint Mary is the co-cathedral of the Roman Catholic Archdiocese of Saint Paul and Minneapolis.

Basilicas are Catholic church buildings that have a designation, conferring special privileges, given by the Pope. Basilicas are distinguished for ceremonial purposes from other churches. The building need not be a basilica in the architectural sense. Basilicas are either major basilicas, of which there are four, all in the Diocese of Rome, or minor basilicas, of which there were 1,810 worldwide as of 2019.