The Battle of Berestechko was fought between the Cossack Hetmanate and Crimean Khanate against the Polish–Lithuanian Commonwealth as a part of the Khmelnytsky Uprising. Near the site of the present-day city of Berestechko in Ukraine, a forces of the Zaporozhian Cossacks and Crimean Tatars under the command of Hetman Bohdan Khmelnytsky, Otaman Tymofiy Khmelnytsky, Colonels Ivan Bohun and Fylon Dzhalaliy with Khan İslâm III Giray and Tugay Bey, who was killed in the battle, was defeated by the Polish–Lithuanian Commonwealth’s forces under the command of the Polish King John II Casimir, Prince Jeremi Wiśniowiecki, Hetmans Marcin Kalinowski and Stanisław Lanckoroński. The battle took place in the Volhynian Voivodeship on the hilly plain south of the Styr River. The Polish–Lithuanian camp was on the Styr River opposite Berestechko and faced south, towards the Zaporozhian Cossacks about two kilometers away, whose right flank was against the Pliashivka (Pliashova) River and the Crimean Tatars on their left flank. It is considered to have been among the largest European land battles of the 17th century.

The Khmelnytsky Uprising, also known as the Cossack–Polish War, or the Khmelnytsky insurrection, was a Cossack rebellion that took place between 1648 and 1657 in the eastern territories of the Polish–Lithuanian Commonwealth, which led to the creation of a Cossack Hetmanate in Ukraine. Under the command of hetman Bohdan Khmelnytsky, the Zaporozhian Cossacks, allied with the Crimean Tatars and local Ukrainian peasantry, fought against Polish domination and Commonwealth's forces. The insurgency was accompanied by mass atrocities committed by Cossacks against the civilian population, especially against the Roman Catholic and Ruthenian Uniate clergy and the Jews, as well as savage reprisals by Jeremi Wiśniowiecki, the voivode of the Ruthenian Voivodeship.