The Battle of Bushy Run was fought on August 5–6, 1763, in western Pennsylvania, between a British column under the command of Colonel Henry Bouquet and a combined force of Delaware, Shawnee, Mingo, and Huron warriors. This action occurred during Pontiac's Rebellion. Though the British suffered serious losses, they routed the tribesmen and successfully relieved the garrison of Fort Pitt.

Henry Bouquet was a Swiss mercenary who rose to prominence in British service during the French and Indian War and Pontiac's War. He is best known for his victory over a Native American force at the Battle of Bushy Run, lifting the siege of Fort Pitt during Pontiac's War. During the conflict Bouquet gained lasting infamy in an exchange of letters with his commanding officer, Jeffery Amherst, who suggested a form of biological warfare in the use of blankets infected with smallpox which were to be distributed to Native Americans. Despite this indictment historians have praised Bouquet for leading British forces in several demanding campaigns on the Western Frontier in which they "protected and rescued" settlers from increasingly frequent attacks.