The Battle of Ecbatana was fought in 129 BC between the Seleucids led by Antiochus VII Sidetes and the Parthians led by Phraates II, and marked the final attempt on the part of the Seleucids to regain their power in the east against the Parthians. After their defeat, the territory of the Seleucids was limited to the area of Syria.

The Seleucid Empire was a Greek power in West Asia during the Hellenistic period. It was founded in 312 BC by the Macedonian general Seleucus I Nicator, following the division of the Macedonian Empire founded by Alexander the Great, and ruled by the Seleucid dynasty until its annexation by the Roman Republic under Pompey in 63 BC.