The Battle of Mine Creek, also known as the Battle of Little Osage, was fought on October 25, 1864, in Linn County, Kansas, as part of Price's Missouri Campaign during the American Civil War. Major-General Sterling Price had begun an expedition in September 1864 to restore Confederate control of Missouri. After being defeated at Westport near Kansas City on October 23, Price's army began to retreat south through Kansas. Early on October 25, Price's army was defeated at the Marais des Cygnes. After Marais des Cygnes, the Confederates fell back, but were stalled at the crossing of Mine Creek while a wagon train attempted to cross.

Price's Missouri Expedition, also known as Price's Raid or Price's Missouri Raid, was an unsuccessful Confederate cavalry raid through Arkansas, Missouri, and Kansas in the Trans-Mississippi Theater of the American Civil War. Led by Confederate Major General Sterling Price, the campaign aimed to recapture Missouri and renew the Confederate initiative in the larger conflict.